Immunological Aspects Related to the Pathophysiology of Multiple Sclerosis and the Possible Checkpoints for Target Therapy: An Integrative Literature Review

Multiple sclerosis (MS) is the most common chronic demyelinating disease of central nervous system (CNS), with an autoimmune inflammatory mechanism, but immunological analysis, described in pathogenesis disease, not attributed or significantly placed universally used criteria. In this regard, literature review aims to highlight aspects that can be both diagnosis and treatment MS. sense, compiled interpreted 41 articles found published between 2010 2020, indexed on platforms: PubMed, Scielo LILACS. Of these only 6 contained proposed inclusion It was possible show CD4 T lymphocytes are activated by antigen presenting cells (microglia B lymphocytes), adopting Th1 profiles (producing IFN-γ TNF-α) Th17 IL-17 IL-22); from activation lymphocytes, they differentiated into plasmocytes will produce IgG4; due action autoreactive there inflammation at neuronal level triggers demyelination. it concluded a need encourage more research regarding reduction response relation MS also encouragement clinical studies already being followed up, given positive results presented them improvement quality life their patients.